How Long Does It Take For Caffeine To Kick In?

Caffeine is a stimulant that helps work our central nervous system, increasing blood pressure and heart rate, giving more energy and keeping us awake. That is why medically, caffeine is suggested for the management of conditions like apnea, bronchopulmonary dysplasia, hypotension and major depressive disorder. You may experience its effects after consuming and it will remain as it is into your body.

When it is ingested in our body, it primarily acts as an adenosine receptor antagonist where it binds to adenosine receptors (A1, A2A, A2B, A3) and prevents activation. It avoids the neurotransmitter adenosine from agonizing receptors, thus reducing drowsiness and fatigue. It also modulates activation of other neurochemical targets as most individual utilize caffeine to increase mental alertness, enhance cognitive function and improve physical performance.

How Long Symptoms Last?

The American Academy of Sleep Medicine says that caffeine’s half-life is up to 5 hours. Half-life is define here as the amount of time it takes for a quantity of a substance to be reduced to half the original content. If you drink 10 milligrams of caffeine, after 5 hours, your body still have 5mg of caffeine.

Its effect can reach to its peak levels within 30-60 minutes of drinking it. This is the time you can experience some nervous effect as well its diuretic effect and you will urinate more due to liquid volume. The remaining half of caffeine that you drink can last for as much as 5 hours. If you are a person sensitive of caffeine, you might feel this symptom for several hours or even days after consumption.

Studies also found that the effects of a cup of coffee and other caffeinated beverages are observable after 10 minutes. It has its peak concentration in the blood after 45 minutes.  But if you will take caffeine in a tablet form like a certain pain reliever which has caffeine, its peak level will still be the same but it takes longer like 60-75 minutes.

But for most people, the caffeine level in their body halves roughly every six house. So it means that 50 percent of the caffeine is still circulating in your system until bedtime.

You might also like to read: How to get caffeine out of your system?

How long does it take for caffeine to kick in?

Caffeine kicks in in your body varies among consumers due to its mode of caffeine administration, genetic mediated differences in caffeine metabolism, and concurrent substances. Research says that when caffeinated beverage is consumed it usually kicks in within 10 to 20 minutes of ingestion. According to U.S. Institute of Medicine, 99% of caffeine consumed is absorbed through the GI tract within 45 minutes of ingestion and distributed throughout the body.

If you are consuming caffeine through in a non-beverage format like chewing gum or capsules, you can get different rate of absorption and onset of action. Caffeine in gums is absorbed quickly and exerts faster onset than other beverage. If you are chewing gums you can feel the effect of its caffeine in less than 10 minutes of consumption. On the other hand if you are consuming it through capsules, it has lower absorption, takes longer time to reach plasma concentration and slower onset of action. It has an estimated time of between 20-40 minutes to kick in.

Research done by Ligouri, Hughes, and Grass, noted that the peak of caffeine plasma is 42 minutes after intake, 39 minutes after cola intake and 67 minutes after capsule consumption. The differences in average time to reach peak plasma concentration is not seen as significant following caffeinated consumption but there’s a significant in delay in attainment of peak plasma when following capsule consumption.

Genes is also a factor on how long does it take for caffeine to kick in in your body. Because caffeine is extensively metabolized by the enzyme CYP1A2, and it likely influence its rate of metabolism and how it takes effect.

When a person has a fast CYP1A2 metabolizers, caffeine kicks in rapidly but its effect may be shorter due to more efficient hepatic metabolism and systematic elimination. But if you are a person of sloe CYP1A2 metabolizers, caffeine most likely kick in at a slower rate but of greater magnitude effect. There is also a possibility that your ADORA gene will influence on how quick caffeine kicks in. If happened that you are carrying certain ADORA gene, it might triggered increase anxiety leading to faster onset of caffeine.

If you are into other medications along with caffeine, it may later caffeine’s onset or duration of effect.

There are many factors that might influence how long it takes for caffeine to take effect. These variables include administration specifics-modality, empty or full stomach), user genetics, caffeine dosage and preexisting caffeine tolerance. Your age, body composition and organ function could also make an impact the amount of time caffeine kicks in.

When caffeine is consume sublingual and intravenous it kicks in faster the orally-administered. The time of the day also influence on the onset of caffeine. It has observed that morning consumption has faster onset of action and more effects than night due to circadian interaction.